The Wednesday college basketball slate in the ACC has plenty of exciting matchups on the docket. Among those contests is the Louisville Cardinals taking on the Indiana Hoosiers, and we have predictions against the spread available for you in this article.

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ACC Picks ATS Today

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Pick: Louisville +2.5 vs. Indiana

• Matchup: Louisville Cardinals vs. Indiana Hoosiers
• Projected Favorite & Spread: Indiana by 2.4 points (Bet on BetMGM)
• Spread: Indiana -2.5
• Time: 12:00 PM ET
• Date: November 27
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Pick: Cornell +9.5 vs. Syracuse

• Matchup: Cornell Big Red at Syracuse Orange
• Projected Favorite & Spread: Syracuse by 1.1 points (Bet on BetMGM)
• Spread: Syracuse -9.5
• Time: 7:00 PM ET
• Date: November 27
• TV Channel: ACC Network Extra

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Pick: Charleston Southern +17.5 vs. Georgia Tech

• Matchup: Charleston Southern Buccaneers at Georgia Tech Yellow Jackets
• Projected Favorite & Spread: Georgia Tech by 14.5 points (Bet on BetMGM)
• Spread: Georgia Tech -17.5
• Time: 7:30 PM ET
• Date: November 27
• TV Channel: ACC Network Extra

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Pick: Cal -19.5 vs. Mercyhurst

• Matchup: Mercyhurst Lakers at California Golden Bears
• Projected Favorite & Spread: Cal by 23.3 points (Bet on BetMGM)
• Spread: Cal -19.5
• Time: 10:00 PM ET
• Date: November 27
• TV Channel: ACC Network Extra

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