Our best bet on the Week 10 FBS schedule, in terms of the point spreads, is Oregon (-3.5) — scroll down for more tips (including parlay possibilities) for both spreads and totals.

See computer picks and insights for that matchup and more in this article.

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College Football Computer Picks – Best Spread Bets

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Pick: Oregon -3.5 vs. Michigan

• Matchup: Oregon Ducks at Michigan Wolverines
• Projected Winner & Margin: Oregon by 18 points
• Time: 3:30 PM ET
• Date: Nov. 2
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo

Pick: Florida +20.5 vs. Georgia

• Matchup: Florida Gators vs. Georgia Bulldogs
• Projected Winner & Margin: Georgia by 8 points
• Time: 3:30 PM ET
• Date: Nov. 2
• TV Channel: ABC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Louisville +8.5 vs. Clemson

• Matchup: Louisville Cardinals at Clemson Tigers
• Projected Winner & Margin: Clemson by 5.1 points
• Time: 7:30 PM ET
• Date: Nov. 2
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Ohio State -3.5 vs. Penn State

• Matchup: Ohio State Buckeyes at Penn State Nittany Lions
• Projected Winner & Margin: Ohio State by 3.8 points
• Time: 12:00 PM ET
• Date: Nov. 2
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Use these spread picks at BetMGM today!

College Football Computer Picks – Best Total Bets

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